A p38α-Selective Chemosensor for use in Unfractionated Cell Lysates
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چکیده
منابع مشابه
A p38α-selective chemosensor for use in unfractionated cell lysates.
Recent efforts have identified the p38α Ser/Thr kinase as a potential target for the treatment of inflammatory diseases as well as non-small cell lung carcinoma. Despite the significance of p38α, no direct activity probe compatible with cell lysate analysis exists. Instead, proxies for kinase activation, such as phosphospecific antibodies, which do not distinguish between p38 isoforms, are ofte...
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Recent efforts have identified the p38 Ser/Thr kinase as a potential target for the treatment of inflamma...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2010
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb100230y